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4-溴苯甲酰氯

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4-溴苯甲酰氯
别名 对溴苯甲酰氯
识别
CAS号 586-75-4  checkY
PubChem 68515
性质
化学式 C7H4BrClO
摩尔质量 219.46 g·mol−1
熔点 42 °C(315 K)
沸点 246 °C(519 K)
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

4-溴苯甲酰氯是一种有机化合物,化学式为C7H4BrClO,它是苯甲酰氯苯环对位的氢被溴取代的化合物。它可由4-溴苯甲酸草酰氯二甲基甲酰胺的催化下于二氯甲烷中反应得到[1],酰氯化试剂也可使用氯化亚砜[2]。它和苯胺三乙胺的存在下于四氢呋喃中反应,可以得到N-苯基-4-溴苯甲酰胺。[3]

参考文献

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  1. ^ Kay Ahn, Markus Boehm, Matthew F. Brown, Jessica Calloway, Ye Che, Jinshan Chen, Kimberly F. Fennell, Kieran F. Geoghegan, Adam M. Gilbert, Jemy A. Gutierrez, Amit S. Kalgutkar, Adhiraj Lanba, Chris Limberakis, Thomas V. Magee, Inish O’Doherty, Robert Oliver, Brandon Pabst, Jayvardhan Pandit, Kevin Parris, Jeffrey A. Pfefferkorn, Timothy P. Rolph, Rushi Patel, Brandon Schuff, Veerabahu Shanmugasundaram, Jeremy T. Starr, Alison H. Varghese, Nicholas B. Vera, Cecile Vernochet, Jiangli Yan. Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism. ACS Chemical Biology. 2016-09-16, 11 (9): 2529–2540 [2021-09-20]. ISSN 1554-8929. doi:10.1021/acschembio.6b00266 (英语). 
  2. ^ Hugo Gallardo, Rodrigo Cristiano, André Vieira, Ricardo Neves Filho, Rajendra Srivastava. Sonogashira Coupling Applied in the Synthesis of 1,2,4-Oxadiazole-Based Nonsymmetrical Liquid Crystals. Synthesis. 2008-02, 2008 (4): 605–609 [2021-09-20]. ISSN 0039-7881. doi:10.1055/s-2008-1032156. (原始内容存档于2018-06-03) (英语). 
  3. ^ Clarice A. D. Caiuby, Matheus P. de Jesus, Antonio C. B. Burtoloso. α-Imino Iridium Carbenes from Imidoyl Sulfoxonium Ylides: Application in the One-Step Synthesis of Indoles. The Journal of Organic Chemistry. 2020-06-05, 85 (11): 7433–7445 [2021-09-20]. ISSN 0022-3263. doi:10.1021/acs.joc.0c00833. (原始内容存档于2021-11-07) (英语).