跳转到内容

3-羟基吡啶-2-甲酸

维基百科,自由的百科全书
3-羟基吡啶-2-甲酸
Skeletal formula of 3-hydroxypicolinic acid
Ball-and-stick model of the 3-hydroxypicolinic acid molecule
IUPAC名
3-Hydroxypyridine-2-carboxylic acid
别名 3-Hydroxypicolinic acid
3-Hydroxy-2-pyridinecarboxylic acid
识别
CAS号 874-24-8  checkY
PubChem 13401
ChemSpider 12827
SMILES
 
  • C1=CC(=C(N=C1)C(=O)O)O
InChI
 
  • 1/C6H5NO3/c8-4-2-1-3-7-5(4)6(9)10/h1-3,8H,(H,9,10)
InChIKey BRARRAHGNDUELT-UHFFFAOYAC
ChEBI 63432
性质
化学式 C6H5NO3
摩尔质量 139.109 g·mol⁻¹
外观 浅黄色针状晶体
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

3-羟基吡啶-2-甲酸是一种有机化合物,化学式为C6H5NO3,它可通过3-氨基吡啶-2-甲酸的重氮化反应制得,它在214~215 °C分解。[1]它和金属盐反应,可以得到相应的配合物。[2][3]它和甲醇硫酸存在下回流反应,可以得到3-羟基吡啶-2-甲酸甲酯。[4]

参考文献

[编辑]
  1. ^ Lewis R. Fibel, Paul E. Spoerri. The Synthesis and Investigation of Pyridine and Pyrazine Analogs of Salicylates 1,2. Journal of the American Chemical Society. 1948-11, 70 (11): 3908–3911 [2022-03-09]. ISSN 0002-7863. doi:10.1021/ja01191a113. (原始内容存档于2022-03-09) (英语). 
  2. ^ Boris-Marko Kukovec, Pedro D.Vaz, Maria José Calhorda, Zora Popović. Structural preferences and isomerism in nickel(II) and copper(II) complexes with 3-hydroxypicolinic acid. Polyhedron. 2012-05, 39 (1): 66–75 [2022-03-09]. doi:10.1016/j.poly.2012.03.040. (原始内容存档于2020-02-19) (英语). 
  3. ^ Tanja Koleša-Dobravc, Keiichi Maejima, Yutaka Yoshikawa, Anton Meden, Hiroyuki Yasui, Franc Perdih. Bis(picolinato) complexes of vanadium and zinc as potential antidiabetic agents: synthesis, structural elucidation and in vitro insulin-mimetic activity study. New Journal of Chemistry. 2018, 42 (5): 3619–3632 [2022-03-09]. ISSN 1144-0546. doi:10.1039/C7NJ04189F (英语). 
  4. ^ Tatiana N. Pashirova, Anissa Braïki, Irina V. Zueva, Konstantin A. Petrov, Vasily M. Babaev, Evgenia A. Burilova, Darya A. Samarkina, Ildar Kh. Rizvanov, Eliana B. Souto, Ludovic Jean, Pierre-Yves Renard, Patrick Masson, Lucia Ya. Zakharova, Oleg G. Sinyashin. Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection. Journal of Controlled Release. 2018-11, 290: 102–111 [2022-03-09]. doi:10.1016/j.jconrel.2018.10.010. (原始内容存档于2021-03-08) (英语).