十四烷基硫代乙酸
| 十四烷基硫代乙酸 | |
|---|---|
| |
| IUPAC名 (Tetradecylsulfanyl)acetic acid 十四烷硫基乙酸 | |
| 别名 | 1-(Carboxymethylthio)tetradecane |
| 识别 | |
| 缩写 | TTA; CMTD |
| CAS号 | 2921-20-2 
|
| PubChem | 114924 |
| ChemSpider | 102869 |
| SMILES |
|
| InChI |
|
| InChIKey | IPBCWPPBAWQYOO-UHFFFAOYAU |
| 性质 | |
| 化学式 | C16H32O2S |
| 摩尔质量 | 288.49 g·mol−1 |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
十四烷基硫代乙酸（TTA）是一种合成脂肪酸，可用作营养补充剂。
TTA是过氧化物酶体增殖物激活受体α（PPARα）激动剂，在体外加快线粒体脂肪酸的氧化。[1]根据啮齿类动物实验的报道，TTA也有其他作用，比如减少炎症[2]，以及预防高脂肪饮食引起的肥胖和胰岛素抵抗。[3]
在人体临床研究中，初步研究的观察结果不一致。一项Ⅰ期研究显示血脂或游离脂肪酸没有显着变化[4]，另一项研究则表明TTA可以减轻2型糖尿病患者的血脂异常。[1]
参考文献
[编辑]- ^ 1.0 1.1 Løvås, K; Røst, TH; Skorve, J; Ulvik, RJ; Gudbrandsen, OA; Bohov, P; Wensaas, AJ; Rustan, AC; et al. Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidation. Diabetes, Obesity & Metabolism. 2009, 11 (4): 304–14. PMID 19267708. S2CID 22883377. doi:10.1111/j.1463-1326.2008.00958.x.
- ^ Bjørndal, B; Grimstad, T; Cacabelos, D; Nylund, K; Aasprong, OG; Omdal, R; Portero-Otin, M; Pamplona, R; Lied, GA; Hausken, Trygve; Berge, Rolf K. Tetradecylthioacetic Acid Attenuates Inflammation and Has Antioxidative Potential During Experimental Colitis in Rats. Digestive Diseases and Sciences. 2012, 58 (1): 97–106. PMID 22855292. S2CID 1539648. doi:10.1007/s10620-012-2321-2. hdl:1956/6530
.
- ^ Madsen, L; Guerre-Millo, M; Flindt, EN; Berge, K; Tronstad, KJ; Bergene, E; Sebokova, E; Rustan, AC; et al. Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance. Journal of Lipid Research. 2002, 43 (5): 742–50. PMID 11971945.
- ^ Pettersen, RJ; Salem, M; Skorve, J; Ulvik, RJ; Berge, RK; Nordrehaug, JE. Pharmacology and safety of tetradecylthioacetic acid (TTA): Phase-1 study. Journal of Cardiovascular Pharmacology. 2008, 51 (4): 410–7. PMID 18427285. S2CID 13784863. doi:10.1097/FJC.0b013e3181673be0.
