User:Surroundedbyluv/草稿01

Solute carrier family 6 (neurotransmitter transporter), member 4
Solute carrier family 6 (neurotransmitter transporter), member 4
标识
代号	SLC6A4; 5-HTT; 5-HTTLPR; 5HTT; HTT; OCD1; SERT; SERT1; hSERT
扩展标识	遗传学：182138 鼠基因：96285 同源基因：817 ChEMBL: 228 GeneCards: SLC6A4 Gene
基因本体论描述
分子功能	· serotonin:sodium symporter activity; · protein binding; · monoamine transmembrane transporter activity; · serotonin transmembrane transporter activity; · myosin binding; · syntaxin-1 binding; · Rab GTPase binding; · cocaine binding; · protein homodimerization activity; · nitric-oxide synthase binding; · actin filament binding;
细胞成分	· cytosol; · plasma membrane; · integral component of plasma membrane; · endosome membrane; · endomembrane system; · neuron projection; · membrane raft;
生物过程	· response to hypoxia; · serotonin transport; · synaptic transmission; · response to nutrient; · memory; · circadian rhythm; · response to toxic substance; · positive regulation of gene expression; · monoamine transport; · thalamus development; · negative regulation of cerebellar granule cell precursor proliferation; · negative regulation of synaptic transmission, dopaminergic; · response to estradiol; · social behavior; · vasoconstriction; · response to drug; · sperm ejaculation; · negative regulation of neuron differentiation; · positive regulation of cell cycle; · negative regulation of organ growth; · brain morphogenesis; · protein oligomerization; · protein homooligomerization; · serotonin uptake; · transmembrane transport; · cellular response to retinoic acid; · cellular response to cGMP;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	6532
Ensembl	ENSG00000108576
UniProt	P31645
mRNA序列	NM_001045
蛋白序列	NP_001036
基因位置	Chr 17:; 30.19 – 30.24 Mb
PubMed查询	[1]
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血清素轉運體 (SERT 或 5-HTT)，鈉離子依賴型血清素轉運體及溶質載體家族6成員4 是一種在人體中 SLC6A4基因所編碼的蛋白質。SERT 是一種負責傳送突觸間隙的血清素到突觸前神經元的單胺轉運蛋白。

功能

血清素轉運體將血清素從突觸間隙發送回突触终扣，阻止了血清素的作用，同時令突觸前神經元能夠重新運用突觸間隙的血清素。

神經元之間的溝通是由神經傳導物質，如細胞之間的血清素轉運來進行。因血清素轉運體使血清素得以重新運用；平衝了血清素於突觸間隙的濃度，因此其作用於接收神經元的受體上。

血清素轉運體也存在於血小板中，作用為一種使血管收縮的物質。

血清素

外部链接

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