3-氯苯甲腈
外觀
3-氯苯甲腈 | |
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別名 | 間氯苯甲腈 |
識別 | |
CAS號 | 766-84-7 ![]() |
PubChem | 13015 |
ChemSpider | 12474 |
SMILES |
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性質 | |
化學式 | C7H4ClN |
摩爾質量 | 137.57 g·mol−1 |
熔點 | 40—41 °C(313—314 K)[1] |
危險性 | |
GHS危險性符號![]() ![]() | |
GHS提示詞 | Danger |
H-術語 | H302, H312, H319 |
P-術語 | P264, P270, P273, P280, P301+312, P302+352, P305+351+338, P312, P322, P330, P337+313, P361, P363, P405 |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
3-氯苯甲腈是一種有機化合物,化學式為ClC6H4CN,它是氯苯甲腈的三種同分異構體之一。
合成與反應
[編輯]通常芳香腈是由氨氧化反應產生的。[2]3-氯苯甲腈可由3-氯苯甲醛和鹽酸羥胺在催化下於100 °C甲苯中反應製得[3],或由3-氯苄胺和碘在乙酸銨水溶液中加熱反應製得。[4]
在銅納米顆粒催化下,它被硼氫化鈉還原,可以得到3-氯苄胺。[5]一些釕催化劑也能催化它在水中水解,得到3-氯苯甲醯胺。[6]
參考文獻
[編輯]- ^ Takashi Keumi, Masakazu Shimada, Toshio Morita, Hidehiko Kitajima. 2-(Trifluoroacetyloxy)pyridine as a Mild Trifluoroacetylating Reagent of Amines and Alcohols. Bulletin of the Chemical Society of Japan. 1990-08, 63 (8): 2252–2256 [2021-12-20]. ISSN 0009-2673. doi:10.1246/bcsj.63.2252. (原始內容存檔於2021-12-20) (英語).
- ^ Pollak, Peter; Romeder, Gérard; Hagedorn, Ferdinand; Gelbke, Heinz-Peter, Nitriles, Ullmann's Encyclopedia of Industrial Chemistry, Weinheim: Wiley-VCH, 2005, doi:10.1002/14356007.a17_363
- ^ Stephan Enthaler, Maik Weidauer, Fanny Schröder. Straightforward zinc-catalyzed transformation of aldehydes and hydroxylamine hydrochloride to nitriles. Tetrahedron Letters. 2012-02, 53 (7): 882–885 [2021-12-20]. doi:10.1016/j.tetlet.2011.12.036. (原始內容存檔於2018-06-13) (英語).
- ^ Yiming Ren, Shuo Jin. Molecular iodine/aqueous NH4OAc: a green reaction system for direct oxidative synthesis of nitriles from amines. Journal of Advanced Oxidation Technologies. 2017-01-01, 20 (1) [2021-12-20]. ISSN 2371-1175. doi:10.1515/jaots-2016-0175. (原始內容存檔於2022-03-28).
- ^ Asghar Zamani, Ahmad Poursattar Marjani, Abbas Nikoo, Mojtaba Heidarpour, Ahmad Dehghan. Synthesis and characterization of copper nanoparticles on walnut shell for catalytic reduction and C-C coupling reaction. Inorganic and Nano-Metal Chemistry. 2018-03-04, 48 (3): 176–181 [2021-12-20]. ISSN 2470-1556. doi:10.1080/24701556.2018.1503676. (原始內容存檔於2022-02-10) (英語).
- ^ Victorio Cadierno, Javier Francos, José Gimeno. Selective Ruthenium-Catalyzed Hydration of Nitriles to Amides in Pure Aqueous Medium Under Neutral Conditions. Chemistry - A European Journal. 2008-07-28, 14 (22): 6601–6605 [2021-12-20]. doi:10.1002/chem.200800847 (英語).