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胸腺喷丁

维基百科,自由的百科全书
胸腺喷丁
临床资料
其他名称(3S)-3-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(2S)-1-hydroxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
ATC码
识别信息
  • L-arginyl-L-lysyl-L-α-aspartyl-L-valyl-L-tyrosine
CAS号69558-55-0  checkY
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
NIAID ChemDB
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.242.320 编辑维基数据链接
化学信息
化学式C30H49N9O9
摩尔质量679.78 g·mol−1
3D模型(JSmol英语JSmol
  • O=C(N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(O)cc1)C(C)C)CC(=O)O)CCCCN)[C@@H](N)CCC/N=C(\N)N
  • InChI=1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t19-,20-,21-,22-,24-/m0/s1 checkY
  • Key:PSWFFKRAVBDQEG-YGQNSOCVSA-N checkY

胸腺喷丁(英语:Thymopentin,别名胸腺五肽)是一种胸腺[1],具有免疫刺激英语immunostimulant作用(作用于T细胞[2]),因此曾在1983-1985年间用于一些对于艾滋病的临床研究中。在针对少数病人进行的短期对应治疗中,胸腺喷丁有助于提升免疫状态。[3][4][5]

参考资料

[编辑]
  1. ^ Peng Y, Chen Z, Yu W, et al. Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells. Cell Biology International. July 2008, 32 (10): 1265–71. PMID 18692582. S2CID 24144448. doi:10.1016/j.cellbi.2008.07.011. 
  2. ^ Liu Z, Zheng X, Wang J, Wang E. Egli M , 编. Molecular analysis of thymopentin binding to HLA-DR molecules. PLOS ONE. 2007, 2 (12): e1348. Bibcode:2007PLoSO...2.1348L. PMC 2137936可免费查阅. PMID 18159232. doi:10.1371/journal.pone.0001348.  开放获取
  3. ^ Mascart-Lemone F, Huygen K, Clumeck N, Brenez D, Bolla K, Duchateau J. Stimulation of cellular function by thymopentin (TP-5) in three AIDS patients. Lancet. 1983, 322 (8352): 735–736. PMID 6193382. S2CID 519367. doi:10.1016/S0140-6736(83)92271-7. 
  4. ^ Clumeck N, Van de Perre P, Mascart-Lemone F, Cran S, Bolla K, Duchateau J. Preliminary results on clinical and immunological effects of thymopentin in AIDS. Int J Clin Pharmacol Res. 1984, 4 (6): 459–463. PMID 6398315. 
  5. ^ Clumeck N, Cran S, Van de Perre P, Mascart-Lemone F, Duchateau J, Bolla K. Thymopentin treatment in AIDS and pre-AIDS patients. Surv Immunol Res. 1985, 4 (1): supp1 58–62 [2021-04-20]. PMID 3898293. doi:10.1007/BF02919057 (不活跃 2021-01-14). (原始内容存档于2021-04-27).