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CXCL1

維基百科,自由的百科全書
Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
PDB rendering based on 1mgs.
有效結構
PDB 直系同源檢索:PDBe, RCSB
標識
代號 CXCL1; FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1
擴展標識 遺傳學155730 鼠基因3037818 同源基因117693 GeneCards: CXCL1 Gene
直系同源體
物種 人類 小鼠
Entrez 2919 330122
Ensembl ENSG00000163739 ENSMUSG00000029379
UniProt P09341 Q6W5C0
mRNA序列 NM_001511 NM_203320
蛋白序列 NP_001502 NP_976065
基因位置 Chr 4:
74.74 – 74.74 Mb
Chr 5:
90.79 – 90.79 Mb
PubMed查詢 [1] [2]

CXCL1(英語:Chemokine (C-X-C motif) ligand 1)是一小分子的細胞因子屬於CXC趨化因子家族[1]。又被稱作生長調節致癌基因α (Growth-regulated oncogene alpha, GROα)[1][2][3]。 趨化因子CXCL1是由巨噬細胞中性粒細胞上皮細胞表達的[4][5]。趨化因子CXCL1對中性粒細胞有細胞趨化作用[1]。CXCL1結合到趨化因子受體CXCR2上而起細胞趨化作用[6]。人類的CXCL1與許多CXC類的趨化因子基因相鄰聚集在第四染色體上[7] 。CXCL1的主要作用包括新血管形成、炎症反應、傷口癒合[6]和腫瘤形成[2][3]

參見

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參考文獻

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  1. ^ 1.0 1.1 1.2 Moser B, Clark-Lewis I, Zwahlen R, Baggiolini M. Neutrophil-activating properties of the melanoma growth-stimulatory activity. J Exp Med. 1990 May 1;171(5):1797-802.
  2. ^ 2.0 2.1 Anisowicz, A., Bardwell, L., Sager, R. Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells. Proc. Nat. Acad. Sci. 84: 7188-7192, 1987.
  3. ^ 3.0 3.1 Richmond, A., Thomas, H. G. (1988) Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution J. Cell. Biochem. 36,185-198
  4. ^ Iida N, Grotendorst GR. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol Cell Biol. 1990 Oct;10(10):5596-9.
  5. ^ Becker S, Quay J, Koren HS, Haskill JS. Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. Am J Physiol. 1994 Mar;266(3 Pt 1):L278-86.
  6. ^ 6.0 6.1 Devalaraja, R. M., Nanney, L. B., Du, J., Qian, Q., Yu, Y., Devalaraja, M. N., Richmond, A. (2000) Delayed wound healing in CXCR2 knockout mice J. Investig. Dermatol. 115,234-244
  7. ^ Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R. Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. EMBO J. 1988 Jul;7(7):2025-33.