ABT-418 是一種有機化合物 ,化學式為C9 H14 N2 O ,由美國雅培 開發,可用作益智藥 和抗焦慮藥 。[ 1] [ 2] [ 3] [ 4] [ 5]
^ Arneric SP, Sullivan JP, Briggs CA, Donnelly-Roberts D, Anderson DJ, Raszkiewicz JL, et al. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization . The Journal of Pharmacology and Experimental Therapeutics. July 1994, 270 (1): 310–318 [2023-11-09 ] . PMID 7518514 . (原始內容存檔 於2005-05-07).
^ Decker MW, Brioni JD, Sullivan JP, Buckley MJ, Radek RJ, Raszkiewicz JL, et al. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization . The Journal of Pharmacology and Experimental Therapeutics. July 1994, 270 (1): 319–328 [2023-11-09 ] . PMID 7913497 . (原始內容存檔 於2005-05-07).
^ Brioni JD, O'Neill AB, Kim DJ, Buckley MJ, Decker MW, Arneric SP. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418 . The Journal of Pharmacology and Experimental Therapeutics. October 1994, 271 (1): 353–361 [2023-11-09 ] . PMID 7965735 . (原始內容存檔 於2009-09-05).
^ Prendergast MA, Terry AV, Jackson WJ, Marsh KC, Decker MW, Arneric SP, Buccafusco JJ. Improvement in accuracy of delayed recall in aged and non-aged, mature monkeys after intramuscular or transdermal administration of the CNS nicotinic receptor agonist ABT-418 . Psychopharmacology. April 1997, 130 (3): 276–284. PMID 9151363 . S2CID 34377165 . doi:10.1007/s002130050240 .
^ Dallanoce C, Magrone P, Matera C, Lo Presti L, De Amici M, Riganti L, et al. Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes. European Journal of Medicinal Chemistry. December 2010, 45 (12): 5594–5601. PMID 20932609 . doi:10.1016/j.ejmech.2010.09.009 .
乙酰膽鹼酯酶抑制劑 其他 β-分泌酶 抑制劑(實驗中)
劃刪除線者臨床試驗已終止
* : 部分地區以有條件批准或保健品等形式上市但缺少臨床試驗/臨床試驗終止
? : 缺少後續研究