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延胡索酰乙酰乙酸

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延胡索酰乙酰乙酸
IUPAC名
(2E)-4,6-Dioxooct-2-enedioic acid
別名 (2E)-4,6-二氧代-2-辛烯二酸
識別
CAS號 28613-33-4  checkY
PubChem 5280398
ChemSpider 4444081
SMILES
 
  • O=C(\C=C\C(=O)O)CC(=O)CC(=O)O
InChI
 
  • 1/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/b2-1+
InChIKey GACSIVHAIFQKTC-OWOJBTEDBU
MeSH Fumarylacetoacetate
性質
化學式 C8H8O6
摩爾質量 200.15 g·mol−1
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

延胡索酰乙酰乙酸(英語:Fumarylacetoacetic acidfumarylacetoacetate,也譯為富馬酰乙酰乙酸)是一種酪氨酸降解的代謝中間產物,分子式為C8H8O6,由馬來酰乙酰乙酸異構酶轉化4-馬來酰乙酰乙酸而來[1],再由延胡索醯乙醯乙酸水解酶(FAH)水解延胡索酸乙醯乙酸[2][3][4]

參考文獻

[編輯]
  1. ^ W. E. Knox and M. LeMay-Knox. The oxidation in liver of l-tyrosine to acetoacetate through p-hydroxyphenylpyruvate and homogentisic acid. Biochem. J. 1951, 49 (5): 686–693. PMC 1197578可免費查閱. PMID 14886367. doi:10.1042/bj0490686. 
  2. ^ Phaneuf D, Labelle Y, Bérubé D, Arden K, Cavenee W, Gagné R, Tanguay RM. Cloning and expression of the cDNA encoding human fumarylacetoacetate hydrolase, the enzyme deficient in hereditary tyrosinemia: assignment of the gene to chromosome 15. Am J Hum Genet. Apr 1991, 48 (3): 525–35. PMC 1682993可免費查閱. PMID 1998338. 
  3. ^ Agsteribbe E, van Faassen H, Hartog MV, Reversma T, Taanman JW, Pannekoek H, Evers RF, Welling GM, Berger R. Nucleotide sequence of cDNA encoding human fumarylacetoacetase. Nucleic Acids Res. Jun 1990, 18 (7): 1887. PMC 330610可免費查閱. PMID 2336361. doi:10.1093/nar/18.7.1887. 
  4. ^ Entrez Gene: FAH fumarylacetoacetate hydrolase (fumarylacetoacetase). (原始內容存檔於2009-10-18).