RBL-1

RBL-1（Rat Basophilic Leukemia cells^[1]）是大鼠嗜碱性粒细胞性白血病（英语：Acute basophilic leukemia）细胞系。由于RBL-1细胞对免疫球蛋白E及其FCER1（英语：FCER1）受体的强烈反应，因此被用于研究过敏反应，并且因为它们在组织培养中具有更高的稳定性，因此它们被用于代替肥大细胞^[2]。同时，RBL细胞有助于对人类患者进行过敏性研究^[3]^[4]。霉浆菌感染极大地影响了生物测定中细胞介体的释放。由于细菌会在RBL-1细胞的表面上生长，并且无法通过光学显微镜对其进行观察，因此需要进行常规的支原体检测。

参考资料[编辑]

^ Bingham, B.R.; Monk, P.N.; Helm, B.A. Defective Protein Phosphorylation and Ca2+ Mobilization Linowa SecretingVariant of the Rat Basophilic Leukemia Cell Line. The Journal of Biological Chemistry. 1994, 269 (30): 19300–19306.
^ Wang, Weimin; et al. Anti-allergic activity of emodin on IgE-mediated activation in RBL-2H3 cells (PDF). Pharmacological Reports. 2012, (64): 1216–1222 [2020-01-08]. ISSN 1734-1140. （原始内容存档 (PDF)于2017-07-05）.
^ Yoo, JM; Sok, DE; Kim, MR. Anti-allergic action of aged black garlic extract in RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.. Journal of medicinal food. 2014-01, 17 (1): 92–102 [2020-01-08]. PMID 24456359. doi:10.1089/jmf.2013.2927. ^{[永久失效链接]}
^ Falcone, FH; Alcocer, MJ; Okamoto-Uchida, Y; Nakamura, R. Use of humanized rat basophilic leukemia reporter cell lines as a diagnostic tool for detection of allergen-specific IgE in allergic patients: time for a reappraisal?. Current allergy and asthma reports. 2015-11, 15 (11): 67 [2020-01-08]. PMID 26452547. doi:10.1007/s11882-015-0568-3. ^{[永久失效链接]}

外部链接[编辑]

Cellosaurus entry for RBL-1（页面存档备份，存于互联网档案馆）

这是一篇分子与细胞生物学（分子细胞生物学）小作品。您可以通过编辑或修订扩充其内容。

[1] Bingham, B.R.; Monk, P.N.; Helm, B.A. Defective Protein Phosphorylation and Ca2+ Mobilization Linowa SecretingVariant of the Rat Basophilic Leukemia Cell Line. The Journal of Biological Chemistry. 1994, 269 (30): 19300–19306.

[2] Wang, Weimin; et al. Anti-allergic activity of emodin on IgE-mediated activation in RBL-2H3 cells (PDF). Pharmacological Reports. 2012, (64): 1216–1222 [2020-01-08]. ISSN 1734-1140. （原始内容存档 (PDF)于2017-07-05）.

[3] Yoo, JM; Sok, DE; Kim, MR. Anti-allergic action of aged black garlic extract in RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.. Journal of medicinal food. 2014-01, 17 (1): 92–102 [2020-01-08]. PMID 24456359. doi:10.1089/jmf.2013.2927. ^{[永久失效链接]}

[4] Falcone, FH; Alcocer, MJ; Okamoto-Uchida, Y; Nakamura, R. Use of humanized rat basophilic leukemia reporter cell lines as a diagnostic tool for detection of allergen-specific IgE in allergic patients: time for a reappraisal?. Current allergy and asthma reports. 2015-11, 15 (11): 67 [2020-01-08]. PMID 26452547. doi:10.1007/s11882-015-0568-3. ^{[永久失效链接]}

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