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DU145细胞

维基百科,自由的百科全书
依托泊苷诱导的DU145细胞凋亡。

DU145(DU-145)是人类前列腺癌细胞系。DU145、PC3和LNCaP被认为是用于治疗研究的标准前列腺癌细胞系[1]。DU145细胞系源自原发性前列腺腺癌的中枢神经系统远端转移,在顶枕开颅手术 (parietooccipital craniotomy) 中被切除[2]雄激素受体阳性的DU145对激素不敏感,并且不表达前列腺特异抗原。 DU145细胞与具有高转移潜力的PC3细胞相比,具有中等的转移潜力[3]

参考资料

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  1. ^ Alimirah, F; Chen, J; Basrawala, Z; Xin, H; Choubey, D. DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation.. FEBS letters. 2006-04-17, 580 (9): 2294–300 [2019-11-25]. PMID 16580667. doi:10.1016/j.febslet.2006.03.041. 
  2. ^ Stone, KR; Mickey, DD; Wunderli, H; Mickey, GH; Paulson, DF. Isolation of a human prostate carcinoma cell line (DU 145).. International journal of cancer. 1978-03-15, 21 (3): 274–81 [2019-11-25]. PMID 631930. doi:10.1002/ijc.2910210305. 
  3. ^ Pulukuri, SM; Gondi, CS; Lakka, SS; Jutla, A; Estes, N; Gujrati, M; Rao, JS. RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo.. The Journal of biological chemistry. 2005-10-28, 280 (43): 36529–40 [2019-11-25]. PMID 16127174. doi:10.1074/jbc.M503111200. 

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