二咖啡酰酒石酸
外观
(重定向自C22H18O12)
二咖啡酰酒石酸 | |
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IUPAC名 (2R,3R)-2,3-Bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}butanedioic acid | |
别名 | Cichoric acid; (2R,3R)-O-Dicaffeoyltartaric acid |
识别 | |
CAS号 | 6537-80-0 ![]() |
PubChem | 5281764 |
ChemSpider | 4445078 |
SMILES |
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InChI |
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InChIKey | YDDGKXBLOXEEMN-IABMMNSOBV |
KEGG | C10437 |
性质 | |
化学式 | C22H18O12 |
摩尔质量 | 474.371 g/mol g·mol⁻¹ |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
二咖啡酰酒石酸(英语:(2R,3R)-O-Dicaffeoyltartaric acid)菊苣酸(英语:Chicoric acid)又称西可酸(英语:Cichoric acid),是一种羟基肉桂酸,属于苯基丙酮类有机化合物,存在于多种植物物种中。 它是咖啡酸和酒石酸的衍生物。[1]
作为区分紫锥菊(Echinacea purpurea)物种的合适标记,它通常使用RP-HPLC和薄层色谱(TLC)方法进行检测。[2]
来源
[编辑]菊苣酸最早是从菊苣(Cichorium intybus)中分离出来的,但也大量存在于紫锥菊中,特别是紫锥菊、蒲公英叶、罗勒、柠檬香草和水生植物,包括藻类和海草。[3][4][5][6]
生物学功能
[编辑]在体外和体内研究中,菊苣酸都被证明可以刺激吞噬细胞,抑制透明质酸酶(一种在人体内分解透明质酸的酶)的功能,保护胶原蛋白免受自由基的损害,以及抑制HIV-1整合酶的功能。[7][8]
参见
[编辑]参考文献
[编辑]- ^ John Shi; Giuseppe Mazza; Marc Le Maguer. Functional Foods: Biochemical and Processing Aspects. CRC Press. 27 February 2002: 241–. ISBN 978-1-4200-1287-3.
- ^ Bauer R, Khan IA, Wagner H. Echinacea-Drogen, Standardisierung mittels HPLC und DC. Deutsche Apotheker Zeitung, 1986, 126:1065–1070. Citation in WHO Monographs on Selected Medicinal Plants - Volume 1
- ^ Chkhikvishvili, I. D.; Kharebava, G. I. Chicoric and Chlorogenic Acids in Plant Species from Georgia. Applied Biochemistry and Microbiology. 2001, 37 (2): 188–191. S2CID 6322156. doi:10.1023/a:1002888016985.
- ^ Lee, Jungmin. Caffeic acid derivatives in dried Lamiaceae and Echinacea purpurea products. Journal of Functional Foods. 2010, 2 (2): 158–162. doi:10.1016/j.jff.2010.02.003.
- ^ Lee, Jungmin; Scagel, Carolyn F. Chicoric acid found in basil (Ocimum basilicum L.) leaves. Food Chemistry. 2009, 115 (2): 650–656. doi:10.1016/j.foodchem.2008.12.075.
- ^ Lee, Jungmin; Scagel, Carolyn F. Chicoric acid: Chemistry, distribution, and production. Frontiers in Chemistry. 2013, 1: 40. Bibcode:2013FrCh....1...40L. PMC 3982519
. PMID 24790967. doi:10.3389/fchem.2013.00040
.
- ^ Mazza, G.; Oomah, B. Dave, Herbs, Botanicals & Teas, CRC Press: 51, 2000 [2008-12-09], ISBN 1-56676-851-9
- ^ Miller, Sandra Carol; Yu, He-Ci, Echinacea, CRC Press: 140, 2004 [2008-12-09], ISBN 0-415-28828-2
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