7α-甲基雌二醇
外观
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临床资料 | |
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其他名称 | 7α-Methyl-E2; 7α-Me-E2; 7α-Methylestra-1,3,5(10)-triene-3,17β-diol |
药物类别 | Estrogen |
识别信息 | |
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CAS号 | 10448-97-2 ![]() |
PubChem CID | |
化学信息 | |
化学式 | C19H26O2 |
摩尔质量 | 286.42 g·mol−1 |
3D模型(JSmol) | |
熔点 | 120 °C(248 °F) [1] |
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7α-甲基雌二醇(英语:7α-Methylestradiol,缩写7α-Me-E2,也称为7α-甲基雌甾-1,3,5(10)-三烯-3,17β-二醇,7α-methylestra-1,3,5(10)-triene-3,17β-diol)是一种人工合成的甾体类雌激素药物,对雌激素受体的亲和力与雌二醇相当[2]。7α-甲基雌二醇同时也是雄激素/同化类固醇曲托龙的活性代谢产物,是曲托龙造成的雌激素效应的原因[3][4]。
另见
[编辑]- 阿美雌酮(7α-甲基雌酮)
参考文献
[编辑]- ^ Steroid with high estrogenic effect(法文). 1965. FR 1418540.
- ^ Raynaud, J.P.; Ojasoo, T.; Bouton, M.M.; Philibert, D. Receptor Binding as a Tool in the Development of New Bioactive Steroids. Drug Design. 1979: 169–214 [2021-06-27]. ISBN 9780120603084. doi:10.1016/B978-0-12-060308-4.50010-X. (原始内容存档于2020-06-04).
- ^ García-Becerra R, Ordaz-Rosado D, Noé G, Chávez B, Cooney AJ, Larrea F. Comparison of 7α-methyl-19-nortestosterone effectiveness alone or combined with progestins on androgen receptor mediated-transactivation. Reproduction. 2012, 143 (2): 211–9. PMID 22065861. doi:10.1530/REP-11-0171
.
- ^ Attardi BJ, Pham TC, Radler LC, Burgenson J, Hild SA, Reel JR. Dimethandrolone (7,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone are not converted to aromatic A-ring products in the presence of recombinant human aromatase. The Journal of Steroid Biochemistry and Molecular Biology. June 2008, 110 (3–5): 214–22. PMC 2575079
. PMID 18555683. doi:10.1016/j.jsbmb.2007.11.009.