4-甲氧基雌二醇
外观
4-甲氧基雌二醇 | |
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IUPAC名 (8R,9S,13S,14S,17S)-4-Methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol | |
别名 | 4-ME2; 4-MeOE2; 4-MeO-E2; 4-Methoxy-17β-estradiol; 4-Methoxyestra-1,3,5(10)-triene-17β-diol; Estra-1,3,5(10)-trien-3,4,17β-triol 4-methyl ether |
识别 | |
CAS号 | 26788-23-8 ![]() |
PubChem | 68578 |
ChemSpider | 61848 |
SMILES |
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ChEBI | 136975 |
性质 | |
化学式 | C19H26O3 |
摩尔质量 | 302.41 g·mol−1 |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
4-甲氧基雌二醇(英语:4-Methoxyestradiol,缩写4-ME2)是一种天然内源性的甲氧基化的儿茶酚雌激素和雌二醇的代谢产物,在体内通过儿茶酚-O-甲基转移酶(COMT)催化中间体4-羟基雌二醇生成[1][2][3],其雌激素活性近似雌酮和4-羟基雌酮[4]。
参考资料
[编辑]- ^ 存档副本. [2021-01-28]. (原始内容存档于2017-01-01).
- ^ Anna R. Hemnes. Gender, Sex Hormones and Respiratory Disease: A Comprehensive Guide. Humana Press. 16 December 2015: 32–. ISBN 978-3-319-23998-9.
- ^ Christian Lauritzen; John W. W. Studd. Current Management of the Menopause. CRC Press. 22 June 2005: 378–379. ISBN 978-0-203-48612-2.
- ^ Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK. Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women. J. Soc. Gynecol. Investig. 2000, 7 (3): 175–83. PMID 10865186. doi:10.1016/s1071-5576(00)00049-6.