11β-羟基睾酮
外观
11β-羟基睾酮 | |
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IUPAC名 11β,17β-dihydroxyandrost-4-ene-3-one | |
识别 | |
CAS号 | 1816-85-9 |
PubChem | 114920 |
ChemSpider | 102866 |
SMILES |
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InChI |
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ChEBI | 81481 |
KEGG | C18075 |
性质 | |
化学式 | C19H28O3 |
摩尔质量 | 304.42 g·mol−1 |
危险性 | |
GHS危险性符号![]() | |
GHS提示词 | Danger |
H-术语 | H351, H360 |
P-术语 | P201, P202, P281, P308+313, P405, P501 |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
11β-羟基睾酮是一种内源性类固醇,是睾酮的代谢产物之一,由类固醇11β羟化酶(CYP11B1)转化睾酮而来[1][2][3]。
参见
[编辑]参考文献
[编辑]- ^ Storbeck KH, Mostaghel EA. Canonical and Noncanonical Androgen Metabolism and Activity. Advances in Experimental Medicine and Biology. 2019, 1210: 239–277. ISBN 978-3-030-32655-5. PMID 31900912. doi:10.1007/978-3-030-32656-2_11.
CYP11B1 and 2 have also been shown to 11β-hydroxylate T, yielding 11β-hydroxytestosterone (11OHT), though the levels produced by the adrenal are low due to the limited availability of adrenal derived T
- ^ Stárka L, Dušková M, Vítků J. 11-Keto-testosterone and other androgens of adrenal origin. Physiological Research. September 2020, 69 (Suppl 2): S187–S192. PMID 33094617. doi:10.33549/physiolres.934516
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- ^ Van Rooyen, D.; Gent, R.; Barnard, L.; Swart, A. C. The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway. The Journal of Steroid Biochemistry and Molecular Biology. 2018, 178: 203–212. PMID 29277707. S2CID 3700135. doi:10.1016/j.jsbmb.2017.12.014.
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