鸭嘴花碱酮
外观
鸭嘴花碱酮 | |
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IUPAC名 (1S)-1-Hydroxy-2,3-dihydropyrrolo[2,1-b]quinazolin-5(1H)-one | |
识别 | |
CAS号 | 486-64-6 |
PubChem | 442935 |
ChemSpider | 391238 |
SMILES |
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ChEBI | 9936 |
性质 | |
化学式 | C11H10N2O2 |
摩尔质量 | 202.21 g·mol−1 |
密度 | 1.5 g/cm3 |
熔点 | 200 - 202 °C(271 K) |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
鸭嘴花碱酮(英语:Vasicinone)是一种喹唑啉生物碱。它在体外显示出支气管扩张作用,[1]但在体内显示出支气管收缩作用。[2]鸭嘴花碱酮被证明具有抗过敏作用。[3]它是在骆驼蓬中发现的。[4]
鸭嘴花碱酮与类似物鸭嘴花碱的组合也被进行了研究。两种生物碱的组合(1:1)在体内和体外均显示出显着的支气管扩张活性。[5]这两种生物碱也是呼吸兴奋剂。[5]鸭嘴花碱具有心脏抑制作用,鸭嘴花碱酮是一种弱心脏兴奋剂;通过结合这两种生物碱可以使效果正常化。[5][3]据报道,鸭嘴花碱具有子宫兴奋作用。[3]
参考资料
[编辑]- ^ Amin, A. H.; Mehta, D. R. A Bronchodilator Alkaloid (Vasicinone) from Adhatoda vasica Nees. Nature. 1959, 184 (4695): 1317. Bibcode:1959Natur.184.1317A. ISSN 0028-0836. PMID 13793186. doi:10.1038/1841317a0
.
- ^ Mehta, D. R.; Naravane, J. S.; Desai, R. M. Vasicinone. A Bronchodilator Principle from Adhatoda Vasica Nees (N. O. Acanthaceae). The Journal of Organic Chemistry. 1963, 28 (2): 445–448. ISSN 0022-3263. doi:10.1021/jo01037a041.
- ^ 3.0 3.1 3.2 Rajani, M; Soni, S; Anandjiwala, Sheetal; Patel, G. Validation of different methods of preparation of Adhatoda vasica leaf juice by quantification of total alkaloids and vasicine. Indian Journal of Pharmaceutical Sciences. 2008, 70 (1): 36–42. ISSN 0250-474X. PMC 2852058
. PMID 20390078. doi:10.4103/0250-474X.40329
.
- ^ Moloudizargari M, Mikaili P, Aghajanshakeri S, Asghari MH, Shayegh J. Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Pharmacogn Rev. July 2013, 7 (14): 199–212. PMC 3841998
. PMID 24347928. doi:10.4103/0973-7847.120524
.
- ^ 5.0 5.1 5.2 Avula, B.; et al. Quantitative determination of vasicine and vasicinone in Adhatoda vasica by high performance capillary electrophoresis (PDF). Die Pharmazie. 2008, 63 (1): 20–22. PMID 18271297. doi:10.1691/ph.2008.7175.