氢氧化胆碱
外观
氢氧化胆碱 | |
---|---|
![]() | |
IUPAC名 Choline hydroxide | |
系统名 2-Hydroxy-N,N,N-trimethylethanaminium hydroxide | |
别名 | |
识别 | |
缩写 | ChOH |
CAS号 | 123-41-1 ![]() |
PubChem | 31255 |
ChemSpider | 28995 |
SMILES |
|
性质 | |
化学式 | C5H15NO2 |
摩尔质量 | 121.18 g·mol−1 |
外观 | 无色澄清的粘稠液体[1]或白色颗粒状固体[2] |
气味 | 类似三甲胺的气味 |
密度 | 1.073 g/cm3(25 °C,46wt%水溶液)[3] |
溶解性(水) | 易溶 |
溶解性 | 48-50% solution of choline hydroxide in water (by weight) is insoluble in toluene.[4] Choline hydroxide
is soluble in ethanol, insoluble in diethyl ether and chloroform.[5] |
折光度n D |
1.4304(46%水溶液)[3] |
结构 | |
配位几何 | Tetrahedral at the nitrogen atom |
危险性 | |
GHS危险性符号![]() ![]() ![]() | |
GHS提示词 | 危险 |
主要危害 | 腐蚀性 |
NFPA 704 | |
闪点 | 92 °F(33 °C)[2] |
致死量或浓度: | |
LD50(中位剂量)
|
21.4 mg/kg (mouse, intravenous)[1] |
相关物质 | |
其他阴离子 | 氯化胆碱 |
其他阳离子 | 四乙基氢氧化铵 |
相关化学品 | 胆碱 |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
氢氧化胆碱是一种有机化合物,化学式为[(CH
3)
3NCH
2CH
2OH]+
OH−
。它可由氯化胆碱和氧化银在水中反应得到[6],或硫酸胆碱和氢氧化钡在水中于50 °C反应制得[7]。它和L-半胱氨酸[8]、1-(氨甲基)环己烷乙酸[9]等羧酸反应,得到相应的离子液体。
参考文献
[编辑]- ^ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Choline hydroxide. pubchem.ncbi.nlm.nih.gov. [2023-02-13]. (原始内容存档于2023-03-27).
- ^ 2.0 2.1 Choline hydroxide | 123-41-1. ChemicalBook. [2023-02-13]. (原始内容存档于2023-02-10).
- ^ 3.0 3.1 存档副本. [2023-02-13]. (原始内容存档于2023-02-10).
- ^ 存档副本 (PDF). [2023-02-13]. (原始内容存档 (PDF)于2023-02-10).
- ^ Rucker RB, Zempleni J, Suttie JW, McCormick DB. Handbook of vitamins
4th. Taylor & Francis. 2007: 459–477. ISBN 9780849340222.
- ^ Yoshiro Tahara, Kaho Morita, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto. Biocompatible Ionic Liquid Enhances Transdermal Antigen Peptide Delivery and Preventive Vaccination Effect. Molecular Pharmaceutics. 2020-10-05, 17 (10): 3845–3856 [2023-02-13]. ISSN 1543-8384. doi:10.1021/acs.molpharmaceut.0c00598. (原始内容存档于2023-02-13) (英语).
- ^ Szarvas, Laszlo; Massonne, Klemens; Maase, Matthias; Oftring, Alfred. Method for producing quaternary ammonium compounds. 2005 WO 2005115969 A1.
- ^ Serena De Santis, Giancarlo Masci, Francesco Casciotta, Ruggero Caminiti, Eleonora Scarpellini, Marco Campetella, Lorenzo Gontrani. Cholinium-amino acid based ionic liquids: a new method of synthesis and physico-chemical characterization. Physical Chemistry Chemical Physics. 2015, 17 (32): 20687–20698 [2023-02-13]. ISSN 1463-9076. doi:10.1039/C5CP01612F (英语).
- ^ Inês C. B. Martins, M. Conceição Oliveira, Hermínio P. Diogo, Luís C. Branco, M. Teresa Duarte. MechanoAPI-ILs: Pharmaceutical Ionic Liquids Obtained through Mechanochemical Synthesis. ChemSusChem. 2017-04-10, 10 (7): 1360–1363 [2023-02-13]. doi:10.1002/cssc.201700153 (英语).