异烟酸甲酯
外观
异烟酸甲酯 | |
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IUPAC名 Methyl pyridine-4-carboxylate | |
别名 | 吡啶-4-甲酸甲酯 |
识别 | |
CAS号 | 2459-09-8 ![]() |
PubChem | 227085 |
ChemSpider | 197537 |
SMILES |
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InChI |
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性质 | |
化学式 | C7H7NO2 |
摩尔质量 | 137.4 g/mol g·mol⁻¹ |
外观 | 无色油状液体[1] |
熔点 | 16.1°C |
沸点 | 208.0 °C |
危险性 | |
GHS危险性符号![]() | |
GHS提示词 | 警告 |
H-术语 | H315, H319, H335 |
P-术语 | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P403+233, P405 |
主要危害 | 有毒 |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
合成
[编辑]异烟酸甲酯可由吡啶-4-甲醛和碘、亚硝酸钠在甲醇中于70 °C反应得到;[1]或由异烟酸和甲醇在硫酸的存在下反应制得[2],其中,异烟酸也可转化为酰氯直接和醇反应得到酯。[3]
N-氧化吡啶-4-甲酸甲酯在雷尼镍的催化下和甲酸铵反应,也能得到异烟酸甲酯。[4]
参考文献
[编辑]- ^ 1.0 1.1 Y. Kiran, Reiko Ikeda, Norio Sakai, Takeo Konakahara. Single-Step Conversion of Electron-Deficient Aldehydes into the Corresponding Esters in Aqueous Alcohols in the Presence of Iodine and Sodium Nitrite. Synthesis. 2010-01, 2010 (02): 276–282 [2021-03-17]. ISSN 0039-7881. doi:10.1055/s-0029-1217121. (原始内容存档于2018-06-04) (英语).
- ^ Serena Berardi, Giuseppina La Ganga, Mirco Natali, Irene Bazzan, Fausto Puntoriero, Andrea Sartorel, Franco Scandola, Sebastiano Campagna, Marcella Bonchio. Photocatalytic Water Oxidation: Tuning Light-Induced Electron Transfer by Molecular Co 4 O 4 Cores. Journal of the American Chemical Society. 2012-07-11, 134 (27): 11104–11107 [2021-03-17]. ISSN 0002-7863. doi:10.1021/ja303951z. (原始内容存档于2022-03-08) (英语).
- ^ Attolino, Emanuele; De Marco, Alessandro; Allegrini, Pietro. Process for the preparation of 3-(4-pyridinyl)propanol and intermediates useful in its synthesis. 2011. WO 2011138250 A1.
- ^ Roman Balicki, Grzegorz Maciejewski. A MILD AND SELECTIVE DEOXYGENATION OF N -OXIDES WITH AMMONIUM FORMATE AS A CATALYTIC HYDROGEN TRANSFER AGENT. Synthetic Communications. 2002-01, 32 (11): 1681–1683 [2021-03-17]. ISSN 0039-7911. doi:10.1081/SCC-120004259 (英语).
拓展阅读
[编辑]- 异烟酸甲酯. ChemicalBook.