延胡索酰乙酰乙酸
外观
(重定向自富马酰乙酰乙酸)
延胡索酰乙酰乙酸 | |
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IUPAC名 (2E)-4,6-Dioxooct-2-enedioic acid | |
别名 | (2E)-4,6-二氧代-2-辛烯二酸 |
识别 | |
CAS号 | 28613-33-4 ![]() |
PubChem | 5280398 |
ChemSpider | 4444081 |
SMILES |
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InChI |
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InChIKey | GACSIVHAIFQKTC-OWOJBTEDBU |
MeSH | Fumarylacetoacetate |
性质 | |
化学式 | C8H8O6 |
摩尔质量 | 200.15 g·mol−1 |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
延胡索酰乙酰乙酸(英语:Fumarylacetoacetic acid或fumarylacetoacetate,也译为富马酰乙酰乙酸)是一种酪氨酸降解的代谢中间产物,分子式为C8H8O6,由马来酰乙酰乙酸异构酶转化4-马来酰乙酰乙酸而来[1],再由延胡索酰乙酰乙酸水解酶(FAH)水解为延胡索酸和乙酰乙酸[2][3][4]。
参考文献
[编辑]- ^ W. E. Knox and M. LeMay-Knox. The oxidation in liver of l-tyrosine to acetoacetate through p-hydroxyphenylpyruvate and homogentisic acid. Biochem. J. 1951, 49 (5): 686–693. PMC 1197578
. PMID 14886367. doi:10.1042/bj0490686.
- ^ Phaneuf D, Labelle Y, Bérubé D, Arden K, Cavenee W, Gagné R, Tanguay RM. Cloning and expression of the cDNA encoding human fumarylacetoacetate hydrolase, the enzyme deficient in hereditary tyrosinemia: assignment of the gene to chromosome 15. Am J Hum Genet. Apr 1991, 48 (3): 525–35. PMC 1682993
. PMID 1998338.
- ^ Agsteribbe E, van Faassen H, Hartog MV, Reversma T, Taanman JW, Pannekoek H, Evers RF, Welling GM, Berger R. Nucleotide sequence of cDNA encoding human fumarylacetoacetase. Nucleic Acids Res. Jun 1990, 18 (7): 1887. PMC 330610
. PMID 2336361. doi:10.1093/nar/18.7.1887.
- ^ Entrez Gene: FAH fumarylacetoacetate hydrolase (fumarylacetoacetase). (原始内容存档于2009-10-18).