喜巴辛
外观
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CAS号 | 6879-74-9 ![]() |
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化学信息 | |
化学式 | C22H35NO2 |
摩尔质量 | 345.53 g·mol−1 |
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喜巴辛(英语:Himbacine)是一种含氮有机化合物,分子式C22H35NO2,最早分离自白木兰属植物( Australian magnolias)的树干中,后可由狄尔斯–阿尔德反应作为关键步骤人工合成[1],可作为蕈毒碱型乙酰胆碱受体的受体拮抗剂[2][3]。
参考文献
[编辑]- ^ Chackalamannil S, Davies RJ, Wang Y, et al. Total Synthesis of (+)-Himbacine and (+)-Himbeline. J. Org. Chem. March 1999, 64 (6): 1932–1940. PMID 11674285. doi:10.1021/jo981983+.
- ^ Malaska MJ, Fauq AH, Kozikowski AP, Aagaard PJ, McKinney M. Chemical Modification of Ring C of Himbacine: Discovery of a Pharmacophoric Element for M2-Selectivity. Bioorganic & Medicinal Chemistry Letters. 1995, 5 (1): 61–66. doi:10.1016/0960-894X(94)00459-S.
- ^ Chackalamannil S, Doller D, McQuade R, Ruperto V. Himbacine analogs as muscarinic receptor antagonists-effects of tether and heterocyclic variations. Bioorganic & Medicinal Chemistry Letters. 2004, 14 (15): 3967–3970. PMID 15225708. doi:10.1016/j.bmcl.2004.05.047.