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去甲基氯巴占

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去甲基氯巴占
IUPAC名
8-Chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
英文名 Norclobazam
别名 脱甲基氯巴占
识别
CAS号 22316-55-8  checkY
性质
化学式 C15H11ClN2O2
摩尔质量 286.71 g·mol−1
密度 1.363±0.06 g·cm−3(20 °C)[1]
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

去甲基氯巴占(英语:norclobazam)是一种有机化合物,化学式为C15H11ClN2O2,它是氯巴占的氮原子上少一个甲基的化合物。它可由N-苯基-4-氯-1,2-苯二胺和丙二酸单甲酯为原料反应制得。[2]它和甲基化试剂(如硫酸二甲酯)反应,可以得到氯巴占[3]它和吗啉反应,可以得到N-(4-吗啉基)去甲基氯巴占。[4]

参考文献

[编辑]
  1. ^ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2021 ACD/Labs). Retrieved from SciFinder. [2021-11-23].
  2. ^ Jagtap, Ashutosh; Gharpure, Milind; Shinde, Navnath; Patil, Navnath; Shah, Chirag; Raut, Changdev; Krishnamurthy, Dhileepkumar. An improved process for the preparation of clobazam and its intermediate. 2017 IN 2015MU00966 A.
  3. ^ Neeraj Kumar, Subba Rao Devineni, Sandesh Bhat, Kadirappa Aggile, Shailendra Kumar Dubey, Pramod Kumar. Potential Impurities of the Anti-epileptic Drug, Clobazam: Synthesis and Characterization. Letters in Organic Chemistry. 2017-11-03, 14 (10) [2021-11-22]. doi:10.2174/1570178614666170623122150. (原始内容存档于2021-05-09) (英语). 
  4. ^ E. Gatta, A. Cupello, M. Di Braccio, G. Grossi, R. Ferruzzi, G. Roma, M. Robello. New 1,5-benzodiazepine compounds: activity at native GABAA receptors. Neuroscience. 2010-03, 166 (3): 917–923 [2021-11-22]. doi:10.1016/j.neuroscience.2010.01.013. (原始内容存档于2018-06-18) (英语).