CD132

CD132
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 2B5I、​2ERJ、​3BPL、​3QAZ、​3QB7、​4GS7
识别号
别名	IL2RG；, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1, interleukin 2 receptor subunit gamma
外部ID	OMIM：308380 MGI：96551 HomoloGene：172 GeneCards：IL2RG
相关疾病
X性联严重复合免疫缺乏症、​combined immunodeficiency, X-linked
为以下药物的标靶
denileukin diftitox
基因位置（人类） 染色体 X染色体 基因座 Xq13.1 起始 71,107,404 bp 终止 71,112,108 bp
基因位置（小鼠） 染色体 小鼠X染色体 基因座 X D|X 43.9 cM 起始 100,307,984 bp 终止 100,311,861 bp
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • interleukin-7 receptor activity • interleukin-2 receptor activity • 血浆蛋白结合 • cytokine receptor activity • interleukin-4 receptor activity • interleukin-2 binding • cytokine binding • interleukin-15 receptor activity 细胞组分 • integral component of membrane • 膜 • 细胞膜 • integral component of plasma membrane • external side of plasma membrane • 核内体 • 细胞质基质 • cell surface • receptor complex 生物学过程 • MAPK cascade • 免疫反应 • viral process • 信号转导 • interleukin-2-mediated signaling pathway • interleukin-4-mediated signaling pathway • interleukin-7-mediated signaling pathway • interleukin-15-mediated signaling pathway • interleukin-9-mediated signaling pathway • 分子功能调控 • cytokine-mediated signaling pathway • interleukin-21-mediated signaling pathway • positive regulation of phagocytosis Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	3561	16186
Ensembl	ENSG00000147168	ENSMUSG00000031304
UniProt	P31785	P34902
mRNA​序列	NM_000206	NM_013563 ​NM_001308535
蛋白序列	NP_000197	NP_001295464 ​NP_038591
基因位置​（UCSC）	Chr X: 71.11 – 71.11 Mb	Chr X: 100.31 – 100.31 Mb
PubMed​查找
维基数据
查看/编辑人类 查看/编辑小鼠

CD132，又称为共用γ链（Common gamma chain，缩写γ_c)，白介素2受体γ亚基（interleukin-2 receptor subunit gamma，缩写IL-2RG）是一种细胞因子受体亚基，存在于至少六种不同的白介素受体中：包括IL-2、IL-4、IL-7、IL-9、IL-15和IL-21的受体。γ_c是I型细胞因子受体家族中的一种糖蛋白，表达于大部分的淋巴细胞群体，哺乳动物的此基因位于X染色体。

延伸阅读

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外部链接

• 医学主题词表（MeSH）：Interleukin+Receptor+Common+gamma+Subunit