利卡司琼
外观
(重定向自C19H27N3O)
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CAS号 | 117086-68-7 ![]() |
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化学式 | C19H27N3O |
摩尔质量 | 313.45 g·mol−1 |
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利卡司琼(INN:ricasetron;开发代号:BRL-46470) 是一种药物,用作血清素5-HT3受体的选择性拮抗剂。[1]它与其他5-HT3拮抗剂一样具有止吐作用,[2]并且具有明显强于其他相关药物的抗焦虑作用,[3]且副作用比苯二氮䓬类抗焦虑药更少。[4][5]然而,它从未被开发用于医疗用途。
参考资料
[编辑]- ^ Newberry NR, Watkins CJ, Sprosen TS, Blackburn TP, Grahame-Smith DG, Leslie RA. BRL 46470 potently antagonizes neural responses activated by 5-HT3 receptors. Neuropharmacology. August 1993, 32 (8): 729–35. PMID 8413836. S2CID 19469831. doi:10.1016/0028-3908(93)90180-B.
- ^ Bermudez J, Sanger GJ. Prolonged anti-emetic activity and 5-HT3-receptor antagonism by BRL 46470 in conscious ferrets. The Journal of Pharmacy and Pharmacology. June 1994, 46 (6): 520–1. PMID 7932054. S2CID 11799269. doi:10.1111/j.2042-7158.1994.tb03843.x.
- ^ Blackburn TP, Baxter GS, Kennett GA, King FD, Piper DC, Sanger GJ, Thomas DR, Upton N, Wood MD. BRL 46470A: a highly potent, selective and long acting 5-HT3 receptor antagonist with anxiolytic-like properties. Psychopharmacology. 1993, 110 (3): 257–64. PMID 7831418. S2CID 9595942. doi:10.1007/BF02251279.
- ^ Link CG, Leigh TJ, Dennison JK. The effects of BRL 46470A, a novel 5-HT3 receptor antagonist, and lorazepam on psychometric performance and the EEG. British Journal of Clinical Pharmacology. April 1993, 35 (4): 395–9. PMC 1381550
. PMID 8485019. doi:10.1111/j.1365-2125.1993.tb04156.x.
- ^ de Souza Silva M, Guimarães FS, Graeff FG, Tomaz C. Absence of amnestic effect of an anxiolytic 5-HT3 antagonist (BRL 46470A) injected into basolateral amygdala, as opposed to diazepam. Behavioural Brain Research. December 1993, 59 (1–2): 141–5. PMID 8155281. S2CID 3999586. doi:10.1016/0166-4328(93)90160-R.
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