腺苷脱氨酶
（重定向自腺苷脱氨酶检测）
| Adenosine/AMP deaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of plasmodium yoelii adenosine deaminase (py02076) | |||||||||
| 鉴定 | |||||||||
| 标志 | A_deaminase | ||||||||
| Pfam | PF00962（旧版） | ||||||||
| Pfam宗系 | CL0034（旧版） | ||||||||
| InterPro | IPR001365 | ||||||||
| PROSITE | PDOC00419 | ||||||||
| SCOP | 1add / SUPFAM | ||||||||
| |||||||||
| Adenosine deaminase (editase) domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 鉴定 | |||||||||
| 标志 | A_deamin | ||||||||
| Pfam | PF02137（旧版） | ||||||||
| InterPro | IPR002466 | ||||||||
| PROSITE | PDOC00419 | ||||||||
| SCOP | 1add / SUPFAM | ||||||||
| |||||||||
| Adenosine/AMP deaminase N-terminal | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 鉴定 | |||||||||
| 标志 | A_deaminase_N | ||||||||
| Pfam | PF08451（旧版） | ||||||||
| InterPro | IPR013659 | ||||||||
| |||||||||
腺苷脱氨酶（英语：Adenosine deaminase）的是一种参与嘌呤代谢作用的酶。它是用作拆解食物组织中的核酸中的腺苷。在人体中，它主要参与了免疫细胞的制造。若该酶突变，会造成T细胞、B细胞及自然杀手细胞皆无法表现的严重复合型免疫缺乏症(SCID)。
反应
[编辑]腺苷脱氨酶对腺苷进行不可逆转的脱氨作用，转化腺苷为相关的核苷肌苷，移除氨基酸组。
病理学
[编辑]腺苷脱氨酶的突变基因使之不容易被表达，这是一些严重复合型免疫缺乏症(SCID)的原因。基因突变令ADA被过度产生是溶血性贫血原因之一。有一些证据表明，一个不同的等位基因(ADA2)可能会导致自闭症。
ADA活性异常与多种疾病相关，如当人体发生结核杆菌侵袭时，人体主要启动细胞免疫，T淋巴细胞和单核巨噬细胞被分枝杆菌激活可引起ADA的活性增强，且间皮细胞吞噬分枝杆菌后产生的特异性细胞因子亦诱导ADA的活性增强。
参考文献
[编辑]深入阅读
[编辑]- da Cunha JG. [Adenosine deaminase. A pluridisciplinary enzyme]. Acta médica portuguesa. 1992, 4 (6): 315–23. PMID 1807098.
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. PMID 2783588. doi:10.1172/JCI113909. - Murray JL, Perez-Soler R, Bywaters D, Hersh EM. Decreased adenosine deaminase (ADA) and 5'nucleotidase (5NT) activity in peripheral blood T cells in Hodgkin disease. Am. J. Hematol. 1986, 21 (1): 57–66. PMID 3010705. doi:10.1002/ajh.2830210108.
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